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ISTURISA WORKS QUICKLY AND LASTS LONG*

Model shown is not an actual patient.

ISTURISA (is tur ee’ sah) is a prescription medicine used to treat adult patients with Cushing’s disease who:

  • Can’t have pituitary surgery, or
  • Have had pituitary surgery but were not cured of their Cushing’s disease

ISTURISA MAY HELP YOU TAKE CONTROL

ISTURISA helps to reduce the amount of cortisol your body makes to help you reach and maintain normal cortisol levels.

By working quickly to get your cortisol levels back to normal*—and keep them there—ISTURISA may help you take control of your Cushing’s disease.

ISTURISA helps bring cortisol levels back to normal

In clinical studies, ISTURISA was proven to lower cortisol levels

After living with symptoms of Cushing’s disease for so many years, you want a solution that works quickly—and lasts long.

*The effectiveness of ISTURISA was studied in 2 clinical trials at different time points in patients with Cushing's disease. Compared with placebo, ISTURISA was proven to lower cortisol levels quickly, and this effect was long-lasting.

IN A STUDY OF 73 PATIENTS, ISTURISA WAS PROVEN TO WORK FAST
77%
had normal cortisol levels at 12 weeks
81%
had normal cortisol levels at 36 weeks
IN ANOTHER STUDY OF 137 PATIENTS, ISTURISA WAS PROVEN TO LAST LONG
2OUT
OF3
had normal cortisol levels at 48 weeks

Improvements were seen in cardiovascular measurements

In a 48-week clinical study, improvements were seen in cardiovascular measurements, including body weight, body mass index (BMI), blood sugars, blood pressure, and cholesterol.†

†The study allowed for the use of blood pressure and diabetes medicines and dose increases in patients already taking these medicines. There was also no control group. So, how much ISTURISA or these other medicines contributed to these specific benefits can't be clearly established.

Improvements were seen in depression symptoms

In a 48-week clinical study, scores on the Beck Depression Inventory decreased by 32% in patients taking ISTURISA.‡

‡The Beck Depression Inventory is a 21-item self-report questionnaire used to evaluate the severity of depression.

Additional benefits of ISTURISA include

  • Dosing that can be individualized to your specific needs
  • Tablets that can be taken with or without food

Dedicated nurse, pharmacist, and insurance-specialist patient support is available through the R.A.R.E.SM program

Wondering if ISTURISA
is right for you?

Download the ISTURISA Informational Brochure
Ready to start a new chapter in your treatment? Learn what to expect when taking ISTURISA Wherever you are in your journey, it’s important to be informed about your condition Learn about Cushing’s disease We're here to support your access to treatment with savings and financial assistance See how R.A.R.E. can help meet your treatment goals

ISTURISA® (osilodrostat) Important Safety Information

Indications and Usage

ISTURISA (osilodrostat) is used to treat adults with Cushing’s disease who cannot have pituitary surgery, or who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.

Important Safety Information:

  • Hypocortisolism: Treatment with ISTURISA may cause symptoms associated with low levels of cortisol in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness. If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.

ISTURISA® (osilodrostat) Important Safety Information

Indications and Usage

ISTURISA (osilodrostat) is used to treat adults with Cushing’s disease who cannot have pituitary surgery, or who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.

Important Safety Information:

  • Hypocortisolism: Treatment with ISTURISA may cause symptoms associated with low levels of cortisol in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness. If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.
  • Heart Problem or Heart Rhythm Problem: ISTURISA may cause an irregular heartbeat which could be a sign of a heart problem called QT prolongation. Call your healthcare provider right away if you have irregular heartbeats.
  • Increase in Other Adrenal Hormone Levels: Your other adrenal hormones may increase when you take ISTURISA. Your healthcare provider may monitor you for the symptoms associated with these hormonal changes while you are taking ISTURISA such as low potassium (hypokalemia), high blood pressure (hypertension), swelling (edema) in the legs, ankles, or other signs of fluid retention, excessive facial or body hair growth (hirsutism), acne (in women). Call your healthcare provider if you have any of these side effects.
  • Most common side effects include very low cortisol levels (adrenal insufficiency), tiredness (fatigue), nausea, headache, swelling of the legs, ankles or other signs of fluid retention (edema). These are not all of the possible side effects of ISTURISA.

To report SUSPECTED SIDE EFFECTS, contact Recordati Rare Diseases Inc. at 1-888-575-8344, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before taking ISTURISA, tell your doctor about all of your medical conditions, including if you:

  • have or had heart problems, such as an irregular heartbeat, including a condition called prolonged QT syndrome (QT internal prolongation). Your healthcare provider will check the electrical signal of your heart (called an electrocardiogram) before you start taking ISTURISA, 1 week after starting ISTURISA, and as needed after that.
  • have a history of low levels of potassium or magnesium in your blood.
  • have liver problems.
  • are breastfeeding or plan to breastfeed. It is not known if ISTURISA passes into your breast milk. You should not breastfeed if you take ISTURISA and for 1 week after stopping treatment.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to treat certain heart problems. Ask your healthcare provider if you are not sure whether your medicine is used to treat heart problems.

Please see the Full Prescribing Information, including the Medication Guide, for ISTURISA and talk with your healthcare provider.