A benign tumor on your pituitary gland causes your body to make too much cortisol from the adrenal glands, which leads to the symptoms of Cushing’s disease. Cortisol—also referred to as the stress hormone—helps control your mood, motivation, and the way you feel.
ENCOURAGEMENT AND
SUPPORT EVERY STEP
OF THE WAY
Model shown is not an actual patient.
There are people out there who understand. Cushing’s Conversations will connect you with someone else who has Cushing’s disease and is managing it with ISTURISA.
Find the support you need with personal, 1:1 phone calls—and remember, you’re not alone. Cushing’s Conversations was created just for you and others taking ISTURISA for Cushing’s disease.
HEAR FROM PATIENTS WHO HAVE TURNED THE PAGE WITH ISTURISA
Name, 51: Title
“Quote”
Andrea, 51
Small business owner
“I have many more good days than bad and renewed hope for my future.”
Alicja, 27
Psychiatric nurse
“I’m still a work in progress—one who sees my future now with a better point of view.”
RESOURCES AND SUPPORT ALONG THE WAY
It is our goal to provide you with support, encouragement, and the appropriate tools and information to help you manage the many aspects of your treatment
Learn more about Cushing’s disease, including how it may be diagnosed and treated.
Download the Cushing’s disease Overview
Get guidance on talking with your endocrinologist about your symptoms, options, and treatment goals.
Download the DoctorLearn more about Cushing’s disease, including how it may be diagnosed and treated.
Wondering if ISTURISA is right for you?
R.A.R.E.SM is your source for savings, access, and support for ISTURISA.
Get guidance on talking with your endocrinologist about your symptoms, options, and treatment goals.
Frequently Asked Questions
Helpful Links
The following websites can provide you with more information about Cushing’s disease.
- Cushing’s Support & Research Foundation (CSRF) www.csrf.net
- Hormone Health Network www.hormone.org
- Pituitary World News www.pituitaryworldnews.org
- Pituitary Network Association www.pituitary.org
ISTURISA® (osilodrostat) Important Safety Information
Indications and Usage
ISTURISA (osilodrostat) is used to treat adults with Cushing’s disease who cannot have pituitary surgery, or who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.Important Safety Information:
- Hypocortisolism: Treatment with ISTURISA may cause symptoms associated with low levels of cortisol in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness. If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.
ISTURISA® (osilodrostat) Important Safety Information
Indications and Usage
ISTURISA (osilodrostat) is used to treat adults with Cushing’s disease who cannot have pituitary surgery, or who have had pituitary surgery, but the surgery did not cure their Cushing’s disease.
Important Safety Information:
- Hypocortisolism: Treatment with ISTURISA may cause symptoms associated with low levels of cortisol in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness. If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.
- Heart Problem or Heart Rhythm Problem: ISTURISA may cause an irregular heartbeat which could be a sign of a heart problem called QT prolongation. Call your healthcare provider right away if you have irregular heartbeats.
- Increase in Other Adrenal Hormone Levels: Your other adrenal hormones may increase when you take ISTURISA. Your healthcare provider may monitor you for the symptoms associated with these hormonal changes while you are taking ISTURISA such as low potassium (hypokalemia), high blood pressure (hypertension), swelling (edema) in the legs, ankles, or other signs of fluid retention, excessive facial or body hair growth (hirsutism), acne (in women). Call your healthcare provider if you have any of these side effects.
- Most common side effects include very low cortisol levels (adrenal insufficiency), tiredness (fatigue), nausea, headache, swelling of the legs, ankles or other signs of fluid retention (edema). These are not all of the possible side effects of ISTURISA.
To report SUSPECTED SIDE EFFECTS, contact Recordati Rare Diseases Inc. at 1-888-575-8344, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before taking ISTURISA, tell your doctor about all of your medical conditions, including if you:
- have or had heart problems, such as an irregular heartbeat, including a condition called prolonged QT syndrome (QT internal prolongation). Your healthcare provider will check the electrical signal of your heart (called an electrocardiogram) before you start taking ISTURISA, 1 week after starting ISTURISA, and as needed after that.
- have a history of low levels of potassium or magnesium in your blood.
- have liver problems.
- are breastfeeding or plan to breastfeed. It is not known if ISTURISA passes into your breast milk. You should not breastfeed if you take ISTURISA and for 1 week after stopping treatment.
Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines used to treat certain heart problems. Ask your healthcare provider if you are not sure whether your medicine is used to treat heart problems.
Please see the Full Prescribing Information, including the Medication Guide, for ISTURISA and talk with your healthcare provider.