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ISTURISA® (osilodrostat) is the first FDA-approved medicine for Cushing’s disease that works by blocking an enzyme that helps make cortisol. This may help you reach and maintain normal cortisol levels.
See the dataHear from others about their
experience with ISTURISA
Hear from others about their experience with ISTURISA
ISTURISA (osilodrostat) is a prescription medicine that is used to treat adults with Cushing’s disease:
It is not known if ISTURISA is safe and effective in children.
ISTURISA (osilodrostat) is a prescription medicine that is used to treat adults with Cushing’s disease:
It is not known if ISTURISA is safe and effective in children.
Before starting ISTURISA tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.
Especially tell your healthcare provider if you take medicines used to treat certain heart problems. Ask your healthcare provider if you are not sure whether your medicine is used to treat heart problems.
ISTURISA can cause serious side effects including:
Low cortisol levels in your blood (hypocortisolism). Tell your healthcare provider right away if you experience more than one of the following symptoms, as these may be symptoms of very low cortisol level, known as adrenal insufficiency: nausea, vomiting, tiredness (fatigue), low blood pressure, stomach (abdominal) pain, loss of appetite, dizziness.
If you get symptoms of hypocortisolism while taking ISTURISA, your healthcare provider may change your dose or ask you to stop taking it.
Increase in other adrenal hormone levels. Your other adrenal hormones may increase when you take ISTURISA. Your healthcare provider may monitor you for the symptoms associated with these hormonal changes while you are taking ISTURISA:
Call your healthcare provider if you have any of these side effects.
The most common side effects of ISTURISA include very low cortisol levels (adrenal insufficiency), tiredness (fatigue), nausea, headache, and swelling of the legs, ankles or other signs of fluid retention (edema).
These are not all the possible side effects of ISTURISA. Call your healthcare provider for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch.
ISTURISA® (osilodrostat) tablets, for oral use, is available as 1 mg and 5 mg tablets.
Please see the full Prescribing Information.
The information contained in this section of the website is intended for US healthcare professionals only. Click CONFIRM to confirm that you are a healthcare professional.
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